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For CSK, because environmental factors such as ultraviolet (UV) radiation are implicated in the pathogenesis, clinical signs may subside in the winter months when light intensity is reduced or if the dog is moved to a lower altitude, or indoors, and thus exposed to less UV radiation.

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Cases of pure red cell aplasia (PRCA) have been reported in patients treated with CellCept in combination with other immunosuppressive agents.

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Recently, vedolizumab was approved by the FDA for the treatment of moderate to severe ulcerative colitis adult patients which are not responding to one or more conventional treatment such as steroids, immunosuppressive agents, or TNF blocker.

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In placebo-controlled olanzapine clinical studies (up to 12 weeks), changes from normal to high in prolactin concentrations were observed in 30% of adults treated with olanzapine as compared to 10.

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The postulated mechanism for this interaction is an antibiotic-induced reduction in glucuronidase-possessing enteric organisms leading to a decrease in enterohepatic recirculation of MPA.

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Between October 1998 and June 2000, 111 patients were screened, 88 of whom underwent randomization ( Figure 2 Enrollment, Treatment Assignments, and Reasons for Withdrawal from the Study or Loss to Follow-up.

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These natural supplements are traditionally believed to stabilize the hyperactive immune system, without causing any side effects.

Safety data are summarized below for all active-controlled trials in renal (2 trials), cardiac (1 trial), and hepatic (1 trial) transplant patients.

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Plasma renin activity and the plasma aldosterone concentration increased normally in response to sodium restriction, and the magnitude of the increases was similar to that in the control transplant recipients ( Table 2 Plasma Renin Activity and Plasma Aldosterone Concentrations, Measured in the Supine Position, in the Proband after Renal Transplantation and in Unrelated Renal-Transplant Recipients.

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