In another study in healthy male volunteers, co-administration with the HIV protease inhibitor ritonavir, which is a highly potent P450 inhibitor, at steady state (500 mg bid) with Fildena (100 mg single dose) resulted in a 300% (4-fold) increase in Cenforce Cmax and a 1000% (11-fold) increase in Cenforce plasma AUC. In addition, in a study performed in healthy male volunteers, co-administration of the HIV protease inhibitor saquinavir, also a CYP3A4 inhibitor, at steady state (1200 mg tid) with Fildena (100 mg single dose) resulted in a 140% increase in Cenforce Cmax and a 210% increase in Cenforce AUC. Based upon measurements of Cenforce in semen of healthy volunteers 90 minutes after dosing, less than 0.001% of the administered dose may appear in the semen of patients.
An evaluation of visual function at doses up to twice the maximum recommended dose revealed no effects of Fildena on visual acuity , intraocular pressure , or pupillometry. Studies have produced relevant data on the effects of Fildena on cardiac output In one small, open-label, uncontrolled, pilot study, eight patients with stable ischemic heart disease underwent Swan-Ganz catheterization. When Fildena 100 mg oral was co-administered with amlodipine, 5 mg or 10 mg oral, to hypertensive patients, the mean additional reduction on supine blood pressure was 8 mmHg systolic and 7 mmHg diastolic.
Blood pressure was measured after administration of Fildena at the same times as those specified for the previous doxazosin studies. Blood pressure was measured after administration of Fildena at the same times as those specified for the first doxazosin study. Effects of Fildena on Blood Pressure When Co-administered with Alpha-Blockers.
Although plasma levels of Cenforce at 24 hours post dose are much lower than at peak concentration, it is unknown whether nitrates can be safely co-administered at this time point see CONTRAINDICATIONS. Based on the pharmacokinetic profile of a single 100 mg oral dose given to healthy normal volunteers, the plasma levels of Cenforce at 24 hours post dose are approximately 2 ng/mL (compared to peak plasma levels of approximately 440 ng/mL).http://efildena.net/fildena-viagra-discount.html